Preclinical researcher

Job Description:
The Preclinical Researcher will be responsible for designing, executing, and analyzing in vitro cell-based, biochemical, and molecular biology assays to generate high-quality data that supports lead selection and optimization. This role requires hands-on expertise in mammalian cell culture, biochemistry, and molecular biology techniques. It involves close collaboration with cross-functional teams to ensure robust and reproducible findings that support the advancement of drug candidates.

Key Responsibilities:
-Plan and execute in vitro studies to characterize mechanisms of action, efficacy, and toxicity, including but not limited to cell viability, cytotoxicity, proliferation, apoptosis, and target engagement.
-Culture and maintain mammalian cell lines (adherent and suspension, primary cells are a plus) using aseptic technique and establish 2D and 3D models as needed.
-Perform biochemical and molecular biology assays (ELISA, qPCR/RT-qPCR, Western blot, flow cytometry, gel electrophoresis, immunofluorescence)
-Design and execute peptide studies, including handling, solubility and stability assessments, and activity assays.
-Analyze and interpret data with rigorous statistics (IC50/EC50 curve fitting, t-tests, ANOVA, and appropriate multiple-comparison controls) and generate precise figures and technical reports to inform project decisions.
-Collaborate cross-functionally to transfer assays, support formulation compatibility screens, align in vitro findings with in vivo pharmacology, contribute to study plans and timelines, and present results to internal teams and leadership.
-Author protocols within the preclinical studies area, ensuring clarity, reproducibility, regulatory alignment, and version control.
-Support administrative tasks related to study execution, including sourcing and purchasing of cell lines, reagents, consumables, and instruments, as well as handling vendor communications and quotation requests
-Research and run efficacy assays aimed at repositioning our medicine and assessing additional molecules for the treatment of diverse indications.

Qualifications:
-Bachelor’s degree or MS in Biology, Biochemistry, Chemistry, Pharmacology, or a related field.
-2+ years (industry or academic core facility) running cell-based assays, end-to-end cell culture, experiment, analysis, and report.
-Hands-on experience with biochemistry and molecular biology techniques (ELISA, qPCR/RT-qPCR, Western blot, flow cytometry, gel electrophoresis, immunofluorescence)
-Experience analyzing and interpreting data from experimental assays in molecular biology and biochemistry, with the ability to clearly present and communicate results in a scientifically rigorous manner.
-Familiar with laboratory safety, biosafety protocols, and handling of hazardous and biological materials
-Excellent command of written and spoken English.

Interested candidates should submit their resume and a cover letter. Please detail your experience in in vitro research, along with the laboratory methods, technical skills, and experimental approaches you are familiar with.

* Salary is negotiable depending on experience and academic background.

Profesional

Universitaria

Biología

Química

Química Farmacéutica

Otra Maestría

2 años de experiencia

1 Vacante